Posted innews Rheumatology
Whole‑Genome Sequencing Reveals HLA, FCGR2B and Complement C4 Copy‑Number as Distinct Genetic Drivers of IgG4‑Related Disease in Japan
A Japanese whole‑genome sequencing study identifies FCGR2B, specific HLA amino‑acid residues, and complement C4 copy‑number variation as independent genetic risk factors for IgG4‑related disease, with PTCH1 and a lncRNA linked to Mikulicz’s disease.