Frailty – Medxy AI

Finerenone Efficacy and Safety Across Frailty Levels in Heart Failure: Insights from the FINEARTS-HF Trial

By MedXY 09/13/2025

This analysis of the FINEARTS-HF trial reveals that finerenone reduces cardiovascular death and heart failure worsening regardless of frailty status, without increasing adverse events, supporting its use in frail patients with HFmrEF or HFpEF.

Clinical Updates Wellness & Lifestyle

Reevaluating Antihypertensive Therapy in Frail Elderly Nursing Home Residents: Insights from the RETREAT-FRAIL Trial

By MedXY 08/30/2025

The RETREAT-FRAIL trial found no survival benefit from progressively reducing antihypertensive medications in frail nursing home residents aged ≥80 with controlled blood pressure, supporting individualized treatment strategies.

Clinical Updates Wellness & Lifestyle

Anti-Inflammatory Dietary Education Reduces Frailty in Colorectal Cancer Patients: Insights from a 12-Week Randomized Controlled Trial

By MedXY 08/18/2025

A 12-week anti-inflammatory dietary education significantly improved frailty, nutritional status, inflammatory biomarkers, and quality of life in frail colorectal cancer patients undergoing chemotherapy.

Clinical Updates Wellness & Lifestyle

Optimizing Anticoagulant Therapy in Frail Elderly AF Patients: Insights from the COMBINE-AF Substudy

By MedXY 08/17/2025

Switching frail, elderly atrial fibrillation patients from warfarin to standard-dose DOAC reduced stroke, fatal and intracranial bleeding, and death, though gastrointestinal bleeding increased. Major bleeding and net clinical outcome remained similar.

Clinical Updates Wellness & Lifestyle

Delirium in Acute General Medicine: A Decade-Long Study on Occurrence, Risk Factors, and Long-Term Outcomes

By MedXY 08/16/2025

This 10-year study from England details delirium's prevalence, associated factors like dementia and frailty, and its lasting impact on mortality and care needs in acute general medicine patients, supporting targeted screening and intervention.

Clinical Updates Wellness & Lifestyle

Frailty as a Predictor of Post-Hospital Outcomes in Older Adults: Implications for Discharge Planning and Care

By MedXY 08/14/2025

Frailty in older hospitalized adults is strongly linked to discharge to post-acute care, increased 90-day readmission rates, and higher mortality, highlighting the need for targeted discharge planning using automated frailty assessments.