Frailty – Medxy AI

Venetoclax‑Obinutuzumab in First‑Line CLL: Efficacy Preserved in Unfit Patients — but Dose Intensity Matters

By MedXY 11/15/2025

Large trial and real‑world data show fixed‑duration venetoclax‑obinutuzumab delivers high response and durable PFS in fit and unfit CLL patients; maintaining adequate venetoclax dose intensity appears important for MRD and long‑term outcomes.

Internal Medicine news Public Health

Extending the Hospital Frailty Risk Score to All Adults: Implications for Hospital Stay, Mortality, and Costs in England

By MedXY 10/20/2025

The Hospital Frailty Risk Score (HFRS) predicts length of stay, mortality, and costs across all adult age groups in England, with stronger effects in older adults, supporting broader clinical use beyond the elderly.

Internal Medicine Public Health Specialties

Unveiling Frailty in England’s Homeless Population: Socioeconomic Insights and Health Implications

By MedXY 10/20/2025

A large-scale analysis reveals high frailty prevalence among people experiencing homelessness in England, highlighting critical socioeconomic factors influencing vulnerability.

Hematology-Oncology news Oncology Specialties

Optimizing Treatment in Frail Elderly with Newly Diagnosed Multiple Myeloma: Insights from the IFM2017-03 Trial on Dexamethasone-Sparing Daratumumab and Lenalidomide Regimen

By MedXY 10/15/2025

The IFM2017-03 phase 3 trial demonstrates that a dexamethasone-sparing regimen combining daratumumab with lenalidomide markedly improves progression-free survival in frail elderly multiple myeloma patients, without increasing serious adverse events.

Cardiology Specialties

Finerenone Efficacy and Safety Across Frailty Levels in Heart Failure: Insights from the FINEARTS-HF Trial

By MedXY 09/13/2025

This analysis of the FINEARTS-HF trial reveals that finerenone reduces cardiovascular death and heart failure worsening regardless of frailty status, without increasing adverse events, supporting its use in frail patients with HFmrEF or HFpEF.

Cardiology news Specialties

Reevaluating Antihypertensive Therapy in Frail Elderly Nursing Home Residents: Insights from the RETREAT-FRAIL Trial

By MedXY 08/30/2025

The RETREAT-FRAIL trial found no survival benefit from progressively reducing antihypertensive medications in frail nursing home residents aged ≥80 with controlled blood pressure, supporting individualized treatment strategies.

Family Medicine & Nutrition Gastroenterology news Oncology Specialties

Anti-Inflammatory Dietary Education Reduces Frailty in Colorectal Cancer Patients: Insights from a 12-Week Randomized Controlled Trial

By MedXY 08/18/2025

A 12-week anti-inflammatory dietary education significantly improved frailty, nutritional status, inflammatory biomarkers, and quality of life in frail colorectal cancer patients undergoing chemotherapy.

Cardiology Specialties

Optimizing Anticoagulant Therapy in Frail Elderly AF Patients: Insights from the COMBINE-AF Substudy

By MedXY 08/17/2025

Switching frail, elderly atrial fibrillation patients from warfarin to standard-dose DOAC reduced stroke, fatal and intracranial bleeding, and death, though gastrointestinal bleeding increased. Major bleeding and net clinical outcome remained similar.

Clinical Updates Emergency Medicine Internal Medicine news Specialties

Delirium in Acute General Medicine: A Decade-Long Study on Occurrence, Risk Factors, and Long-Term Outcomes

By MedXY 08/16/2025

This 10-year study from England details delirium's prevalence, associated factors like dementia and frailty, and its lasting impact on mortality and care needs in acute general medicine patients, supporting targeted screening and intervention.

Emergency Medicine Family Medicine & Nutrition news Specialties

Frailty as a Predictor of Post-Hospital Outcomes in Older Adults: Implications for Discharge Planning and Care

By MedXY 08/14/2025

Frailty in older hospitalized adults is strongly linked to discharge to post-acute care, increased 90-day readmission rates, and higher mortality, highlighting the need for targeted discharge planning using automated frailty assessments.