dexmedetomidine – Medxy AI

Optimizing the Surgical Field: Diltiazem and Esmolol Excel in Controlled Hypotension for Endoscopic Sinus Surgery

By MedXY 01/30/2026

This systematic review and network meta-analysis of 52 randomized trials evaluates pharmacological agents for controlled hypotension in ESS, identifying diltiazem, esmolol, and dexmedetomidine as the most effective for reducing intraoperative bleeding and improving surgical visualization.

Anesthesiology Cardiology news

Perioperative Dexmedetomidine Fails to Reduce Major Complications After Cardiac Surgery: Results from the DOCS Trial

By MedXY 01/07/2026

The DOCS trial, a multi-center randomized controlled study, found that perioperative dexmedetomidine infusion did not significantly reduce in-hospital mortality or major complications in adults undergoing cardiac surgery with cardiopulmonary bypass, challenging the hypothesis of its broad organ-protective benefits.

Anesthesiology Critical Care news

Alpha-2 Agonists vs. Propofol: The A2B Trial Challenges the Paradigm of Expedited Extubation in the ICU

By MedXY 12/26/2025

The A2B randomized clinical trial reveals that dexmedetomidine- or clonidine-based sedation does not significantly reduce the time to successful extubation compared to propofol in critically ill patients, while increasing the risk of bradycardia and agitation.

Anesthesiology Critical Care news

Dexmedetomidine Reduces Agitation and Accelerates Recovery in Non-Intubated ICU Patients with Hyperactive Delirium: Insights from the 4D Trial

By MedXY 12/26/2025

The 4D randomized clinical trial demonstrates that dexmedetomidine significantly reduces agitation duration and improves clinical outcomes in non-intubated ICU patients with hyperactive delirium, providing a safe and effective alternative to standard care without increasing the need for mechanical ventilation.

Anesthesiology Critical Care news

Dexmedetomidine for Analgesia in Nonintubated Patients With Traumatic Rib Fractures: A Randomized Clinical Trial Analysis

By MedXY 10/10/2025

This trial found that adjunctive dexmedetomidine did not reduce opioid use, pain scores, or pulmonary complications in nonintubated ICU patients with traumatic rib fractures, challenging its routine analgesic use in this setting.

Anesthesiology General Surgery Oncology Specialties

Optimizing Anesthesia in Elderly NSCLC Patients: Impact of Midazolam and Dexmedetomidine Co-Administration on Hemodynamics and Stress Response

By MedXY 09/15/2025

Co-administering midazolam with dexmedetomidine in elderly NSCLC patients undergoing lobectomy enhances hemodynamic stability and reduces perioperative stress response, potentially improving recovery outcomes without increasing adverse events.