critical care – Page 3

$Adjunctive Terlipressin in Refractory Septic Shock: Lowers High-Dose Catecholamine Need at 6 Hours but No Mortality Benefit$

Adjunctive Terlipressin in Refractory Septic Shock: Lowers High-Dose Catecholamine Need at 6 Hours but No Mortality Benefit

By MedXY 11/07/2025

In a double-blind RCT of 130 patients with refractory septic shock, terlipressin increased the proportion achieving MAP ≥65 mmHg with low catecholamine exposure at 6 hours versus placebo but did not change 28-day mortality; digital ischemia rates were high in both groups.

Critical Care Nephrology news

Renal Contrast‑Enhanced Ultrasound Is Reproducible in Stable Critically Ill Patients — mTT Is the Most Robust Metric

By MedXY 11/06/2025

In stable critically ill patients, contrast‑enhanced ultrasound (CEUS) renal perfusion metrics are reproducible; amplitude measures (RBV, PI) are more dose‑sensitive while mean transit time (mTT) shows greater robustness across infusion changes.

Critical Care news Respiratory

Rescue Noninvasive Ventilation After Extubation: High Failure but No Clear Increase in Hospital Mortality — A Post‑hoc RINO Trial Analysis

By MedXY 11/06/2025

A post‑hoc analysis of the RINO trial found rescue NIV for post‑extubation respiratory failure had a 58% failure rate but was associated with lower ICU mortality and no clear increase in hospital mortality when applied with prespecified re‑intubation criteria.

Anesthesiology Critical Care news

Continuous Intravenous Sedation Produces Novel EEG ‘Ups’ in Early Acute Hypoxemic Respiratory Failure — Implications for Monitoring and Outcomes

By MedXY 11/06/2025

In mechanically ventilated patients with early acute hypoxemic respiratory failure, continuous IV sedation produces EEG patterns (EEG Ups) not seen in natural sleep; these patterns correlate with sedation dose, drug combinations, clinical sedation depth, and ICU mortality.

Critical Care Emergency Medicine news

Noninferiority of Deferring Early Arterial Catheterization in Shock Management: Insights from a Multicenter RCT

By MedXY 10/31/2025

A large multicenter trial demonstrated that deferring early arterial catheter insertion in ICU patients with shock is noninferior to early invasive monitoring for 28-day mortality, with fewer catheter-related complications and comparable safety profiles.

Critical Care Rehabilitation Medicine Respiratory

Optimizing Critical Care Outcomes: The Pivotal Role of Rehabilitation and Physiotherapy

By MedXY 10/23/2025

This article reviews current evidence and clinical practices for physiotherapy in ICU settings, emphasizing benefits, safety, staffing challenges, and future directions in critical care rehabilitation.

Critical Care Emergency Medicine news

Innovative Respiratory Gas Delivery Device Significantly Extends Survival Time in Simulated Critical Avalanche Burial

By MedXY 10/10/2025

A randomized clinical trial demonstrates that a novel avalanche safety device delaying hypoxia and hypercapnia can extend survival time beyond the critical 35-minute asphyxiation window during avalanche burial.

Critical Care Emergency Medicine news

Exertional Heat Stroke: Critical Insights for Emergency Physicians

By MedXY 10/08/2025

Exertional heat stroke (EHS) is a life-threatening condition characterized by hyperthermia and CNS dysfunction, necessitating rapid recognition and intervention to prevent multi-organ failure and death. This article reviews its pathophysiology, diagnosis, and management essentials for clinicians.

Clinical Updates Critical Care news Specialties

Proportional-Assist Ventilation vs. Pressure-Support Ventilation: Implications for Liberation from Mechanical Ventilation

By MedXY 09/19/2025

An international trial comparing proportional-assist ventilation (PAV+) with pressure-support ventilation (PSV) showed no significant difference in time to successful liberation from mechanical ventilation among critically ill adults.

Clinical Updates Critical Care Specialties

Proportional-Assist Ventilation and Pressure-Support Ventilation: Comparative Impact on Mechanical Ventilation Duration in Critical Care

By MedXY 09/19/2025

A comprehensive international trial showed that proportional-assist ventilation (PAV+) does not significantly shorten the time to liberation from mechanical ventilation compared to pressure-support ventilation (PSV) in critically ill adults, with comparable safety and secondary outcomes.

Cardiology Specialties

Long-Term Functional Recovery and Survival after VA-ECMO: Insights from a 26-Center Prospective Cohort Study

By MedXY 08/17/2025

A multicenter study reveals that 30% of adult VA-ECMO patients survive 12 months without new disability, with most disability developing within the first 6 months. Functional independence and employment improve by 12 months post-ECMO.

Critical Care news Specialties

Normosol-R versus Lactated Ringers in Critical Care: Evaluating Balanced Crystalloids for Optimal Patient Outcomes

By MedXY 08/13/2025

A randomized trial evaluating Normosol-R versus lactated Ringers in critically ill adults found no significant difference in acid-base balance, kidney replacement therapy rates, or 30-day mortality, supporting comparable efficacy between these balanced crystalloids.

Critical Care news Specialties

UK-ROX Trial: Conservative Oxygen Strategy in Mechanically Ventilated ICU Patients — No 90‑Day Survival Benefit

By MedXY 08/09/2025

The UK-ROX randomized trial (n=16,500) found that targeting SpO2 90% (88–92%) to reduce oxygen exposure did not reduce 90‑day all‑cause mortality versus usual care in mechanically ventilated adults.