coronary artery disease

Obstructive Coronary Artery Disease Does Not Diminish Long-Term Health Status or Clinical Efficacy After TAVR: 3-Year Insights from SCOPE I

By MedXY 12/21/2025

A post hoc analysis of the SCOPE I trial reveals that obstructive coronary artery disease (CAD) does not significantly impact 3-year survival or patient-reported health status following TAVR, questioning the routine necessity of periprocedural PCI in this population.

Cardiology news

Reticulated Platelets Drive Prothrombotic Signalling in Coronary Artery Disease — GPVI and PI3K Identified as Actionable Targets

By MedXY 12/02/2025

A multidimensional study of 95 CAD patients shows that RNA-rich reticulated platelets exhibit a distinct prothrombotic transcriptomic and proteomic signature with upregulated GPVI and PI3K signalling; GPVI and PI3K inhibition reduced RP-driven thrombogenicity ex vivo.

Cardiology news

CABG Provides Superior Long-Term Outcomes to PCI in Women with Chronic Severe CAD: Real‑World Ontario Cohort Shows Lower MACCE and Mortality

By MedXY 11/28/2025

In a propensity‑matched Ontario cohort of women with chronic severe coronary artery disease, CABG was associated with lower long‑term MACCE and all‑cause mortality than PCI over a median 5.1 years.

Cardiology news

Genetic Insights into LDL Cholesterol and Coronary Artery Disease Risk Across Diverse Global Populations

By MedXY 10/30/2025

A large-scale multi-ancestry genetic study confirms consistent associations between LDL cholesterol levels and coronary artery disease risk across six global ancestries, highlighting the generalizability of LDL-C lowering interventions beyond European populations.

AI Cardiology Internal Medicine news Rehabilitation Medicine

Revolutionizing Cardiac Rehab: The Impact of Wearable Technology and Online Coaching

By MedXY 10/24/2025

This review discusses a landmark study demonstrating how wearable devices and online coaching improve exercise capacity in coronary artery disease patients, highlighting advancements in remote cardiac rehabilitation.

Cardiology Rehabilitation Medicine

X-CircuiT versus Conventional Exercise in Home-Based Cardiac Rehabilitation: A Non-Inferiority Randomized Trial for CAD Patients

By MedXY 10/23/2025

This randomized controlled non-inferiority trial demonstrates that X-CircuiT, a smartphone-guided multi-component exercise regime, is as effective and safe as conventional exercise in improving fitness in home-based cardiac rehabilitation for patients with coronary artery disease and risk factors.

Cardiology news

Clopidogrel versus Aspirin for Secondary Prevention in Coronary Artery Disease: A Comprehensive Meta-Analysis

By MedXY 10/11/2025

This meta-analysis of nearly 29,000 CAD patients shows clopidogrel monotherapy reduces major cardiovascular events more than aspirin without increasing major bleeding risk, supporting clopidogrel as preferred secondary prevention.

Clinical Updates news

Age-Stratified Outcomes of Rivaroxaban Monotherapy in Atrial Fibrillation with Stable Coronary Artery Disease: Insights from the AFIRE Trial

By MedXY 09/27/2025

This post hoc AFIRE trial analysis shows rivaroxaban monotherapy reduces major cardiovascular events and major bleeding across age groups in AF with stable CAD, with notable age-related efficacy and safety trends warranting further research.

Cardiology news

Long-Term Survival Outcomes After Initial Stress Testing Versus Coronary CTA in Suspected CAD: Insights from the PROMISE Trial

By MedXY 09/27/2025

The PROMISE trial's 10-year follow-up shows no difference in all-cause or cardiovascular mortality between initial functional stress testing and anatomic coronary CTA in symptomatic patients with suspected coronary artery disease.

Cardiology Family Medicine & Nutrition Specialties

Long-Term Outcomes of the DASH Intervention in Nonobstructive Coronary Artery Disease: Follow-Up of the DISCO-CT Study

By MedXY 09/16/2025

A one-year DASH diet intervention led to sustained suppression of proatherogenic chemokine CXCL4 and fewer major cardiovascular events over six years despite reduced adherence and partial loss of initial benefits in nonobstructive CAD patients.

AI Cardiology Specialties

Harnessing Machine Learning to Predict High-Risk Coronary Artery Disease: Insights from the SCOT-HEART Trial

By MedXY 09/14/2025

Machine learning models trained on clinical data improve prediction of coronary artery disease on CT scans compared to traditional risk scores, potentially guiding better resource utilization in cardiovascular care.

Cardiology news Specialties

Understanding Organ Calcification: When to Worry and What to Do

By MedXY 09/03/2025

Discover the causes of organ calcification, differentiate harmless from dangerous types, and learn how to interpret your health reports with expert advice.

Cardiology news Specialties

Clopidogrel Surpasses Aspirin: Comprehensive Meta-Analysis Shows Superior Secondary Prevention in Coronary Artery Disease

By MedXY 09/02/2025

A large meta-analysis in The Lancet demonstrates that clopidogrel reduces MACCE risk by 14% over aspirin in CAD secondary prevention, with comparable safety over 5.5 years.

Cardiology Nephrology Specialties

Comparative Effectiveness of Prasugrel Versus Clopidogrel in Patients with Impaired Renal Function: A Clinical Review

By MedXY 08/21/2025

Prasugrel demonstrates a more rapid and significant inhibition of platelet aggregation than clopidogrel in patients with stable coronary artery disease and impaired renal function, particularly within the first week of therapy.