Cardiology – Page 2

Elevated Admission D-dimer: A Potent New Predictor of In-Hospital Mortality in Takotsubo Syndrome

By MedXY 01/05/2026

A retrospective study of 580 TTS patients demonstrates that admission D-dimer levels ≥3.5 µg/mL are associated with a seven-fold increase in in-hospital mortality, significantly improving the predictive accuracy of the traditional InterTAK Prognostic Score.

Cardiology news

Persistent Healthcare Burden in Women with Chest Pain Despite No Obstructive Coronary Artery Disease: Insights from the WOMANOCA Study

By MedXY 01/04/2026

A nationwide Danish cohort study reveals that women with angina or non-specific chest pain and no obstructive coronary artery disease face significantly higher rates of cardiac readmissions and primary care consultations compared to asymptomatic peers, highlighting a substantial healthcare burden.

Cardiology Critical Care news

High-Acuity Presentations with Favorable Outcomes: The Paradox of Young Adults in the Cardiac ICU

By MedXY 01/03/2026

A large-scale registry study reveals that young adults (18-39) in the Cardiac Intensive Care Unit present with higher rates of cardiogenic shock and cardiac arrest compared to older adults, yet demonstrate significantly higher survival rates despite more intensive resource utilization.

Cardiology news

Precision Risk Assessment in CPVT: New Validated Models Predict Arrhythmic Events on Beta-Blocker Therapy

By MedXY 01/03/2026

A landmark study has developed and validated the first clinical risk prediction models for RYR2-mediated CPVT, identifying key factors like age at treatment and prior symptoms that determine life-threatening outcomes despite beta-blocker therapy.

Cardiology Emergency Medicine news

The Price of Time: 20-Year Study Reveals Pre-Hospital Delay as a Critical Driver of STEMI Mortality

By MedXY 01/03/2026

A 20-year analysis of 89,155 patients from the SWEDEHEART registry confirms that pre-hospital delay independently predicts short- and long-term mortality. Despite advances in reperfusion, women, elderly patients, and those with diabetes consistently experience significantly longer delays, highlighting a critical need for targeted public health interventions.

Cardiology Internal Medicine news

Guided Antiplatelet De-escalation Proves Safe in High Atherothrombotic Risk ACS Patients: Insights from TROPICAL-ACS

By MedXY 01/02/2026

Post-hoc analysis of the TROPICAL-ACS trial demonstrates that platelet function testing-guided de-escalation of dual antiplatelet therapy from prasugrel to clopidogrel is safe and effective in ACS patients, regardless of their atherothrombotic risk profile, offering a viable strategy for individualized care.

Cardiology news

Timing Matters: Platelet Reactivity Predicts Early Events While Clinical Risk Governs Long-Term Outcomes Post-PCI

By MedXY 12/30/2025

Analysis of the PTRG-DES registry shows that platelet reactivity drives early ischemic risk post-PCI, while clinical risk factors (TRS2P) determine long-term prognosis, suggesting a need for temporally tailored secondary prevention strategies.

Cardiology news

Refining Risk: Clinical and Angiographic Predictors of Postprocedural Troponin Elevation in Elective PCI

By MedXY 12/30/2025

A comprehensive analysis of over 10,000 patients identifies key risk factors for post-PCI troponin increase, highlighting the protective role of intravascular imaging and the prognostic impact of different myocardial infarction definitions.

Cardiology Critical Care news

Beyond Chronological Age: How Frailty Dictates Survival and Functional Recovery After Out-of-Hospital Cardiac Arrest

By MedXY 12/28/2025

A secondary analysis of the TTM2 trial reveals that frailty is a potent predictor of mortality and poor neurological outcomes after out-of-hospital cardiac arrest, with severely frail patients facing a 35-fold higher risk of poor functional recovery.

Cardiology Internal Medicine news

Redefining Iron Deficiency in Heart Failure: Why TSAT and Serum Iron Outperform Ferritin for Prognosis

By MedXY 12/26/2025

Recent large-scale studies, including HEART-FID and major national registries, demonstrate that transferrin saturation (TSAT) and serum iron levels are more accurate predictors of functional capacity and mortality in heart failure than traditional ferritin-based definitions.

Cardiology Internal Medicine news

Beyond the Scale: Abdominal Adiposity Outperforms BMI in Predicting Outcomes for HFpEF and HFmrEF

By MedXY 12/26/2025

A pooled analysis of 21,479 HFpEF/HFmrEF patients reveals that waist-to-height ratio is a superior, linear predictor of mortality and heart failure events compared to BMI. Even in non-obese BMI categories, nearly 90% of patients exhibit excess abdominal adiposity, necessitating a shift in clinical assessment.

Cardiology news

Finerenone and Hypotension Risk in Heart Failure: Evidence from the FINEARTS-HF Trial

By MedXY 12/26/2025

This analysis of the FINEARTS-HF trial identifies that while finerenone increases hypotension risk in HFmrEF and HFpEF patients, its clinical benefits persist. The study highlights key predictors of hypotension, such as low baseline blood pressure and advanced age, emphasizing the need for vigilant clinical monitoring.

Cardiology news

Coramitug Significantly Reduces NT-proBNP in Transthyretin Amyloid Cardiomyopathy: Phase 2 Trial Results

By MedXY 12/25/2025

A Phase 2 randomized trial shows that coramitug, a monoclonal antibody targeting misfolded transthyretin, significantly reduced NT-proBNP levels by 48% in patients with ATTR-CM. While functional outcomes remained stable over 52 weeks, the results suggest a breakthrough in active amyloid clearance.

Cardiology Internal Medicine news

N-Palmitoyl Glutamine: A Novel Molecular Link Between Exercise, Mitochondrial Efficiency, and Human Longevity

By MedXY 12/25/2025

A groundbreaking study identifies N-palmitoyl glutamine (NPG) as a key molecular transducer of cardiorespiratory fitness. NPG correlates with VO2max, increases with exercise training, predicts lower mortality, and directly enhances mitochondrial function, offering a potential therapeutic target for cardiometabolic health.

Cardiology news

Beyond Vagal Tone: Genetic Predisposition and Physical Fitness Drive Profound Bradycardia in Elite Athletes

By MedXY 12/24/2025

A comprehensive study of elite endurance athletes reveals that resting bradycardia (≤40 bpm) is common and driven by both fitness and a lower polygenic risk score for heart rate. These findings suggest that genetics may predispose individuals to athletic success and sinus node remodeling.

Cardiology news

Mavacamten Significantly Reduces Myocardial Stress and Injury in Nonobstructive HCM: Insights From the ODYSSEY-HCM Trial

By MedXY 12/24/2025

While the ODYSSEY-HCM trial missed its primary functional endpoints, a new exploratory analysis reveals that mavacamten significantly reduces NT-proBNP and hs-cTnI levels in patients with nonobstructive hypertrophic cardiomyopathy, suggesting a potent biological effect on myocardial wall stress and chronic injury.

Cardiology Emergency Medicine news

High-Sensitivity Cardiac Troponin Risk Stratification Safely Accelerates ED Discharge and Improves 1-Year Outcomes

By MedXY 12/24/2025

A secondary analysis of the HiSTORIC trial reveals that using high-sensitivity cardiac troponin for risk stratification significantly reduces ED length of stay and increases safe discharge rates for low- and intermediate-risk patients, with improved 1-year safety outcomes.

Cardiology news

Long-Term Silicon Exposure Fails to Predict Coronary Artery Disease Severity or Systemic Inflammation

By MedXY 12/24/2025

A pilot study evaluating hair silicon as a long-term mineral marker found no significant association between silicon concentrations and coronary artery disease (CAD) severity or inflammatory markers, suggesting silicon may be metabolically neutral in advanced atherosclerosis.

Cardiology Internal Medicine news

Aggressive LDL-C Lowering Mitigates Neoatherosclerosis Risk: Insights from the CONNECT Trial

By MedXY 12/24/2025

This secondary analysis of the CONNECT trial demonstrates that achieving guideline-endorsed LDL-C levels significantly lowers the risk of neoatherosclerosis three years post-DES implantation in STEMI patients, underscoring the vital role of aggressive lipid management in secondary prevention.

Cardiology news

Obstructive Coronary Artery Disease Does Not Diminish Long-Term Health Status or Clinical Efficacy After TAVR: 3-Year Insights from SCOPE I

By MedXY 12/21/2025

A post hoc analysis of the SCOPE I trial reveals that obstructive coronary artery disease (CAD) does not significantly impact 3-year survival or patient-reported health status following TAVR, questioning the routine necessity of periprocedural PCI in this population.