autophagy – Medxy AI

Repurposing Antihypertensive Drug Trazosin to Delay Vascular Aging: A Breakthrough in Atherosclerosis Management

By MedXY 09/18/2025

New research identifies transcription factor ATF3 as a key regulator of vascular smooth muscle cell aging and reveals low-dose trazosin, a commonly used antihypertensive, as a potential therapy to delay vascular aging and atherosclerosis progression via autophagy enhancement.

Family Medicine & Nutrition Gastroenterology news Specialties

Linarin as a Multifaceted Therapeutic Agent for NAFLD: Modulation of PI3K/Akt/mTOR, Autophagy, and Gut Microbiota

By MedXY 09/07/2025

Linarin shows promise in mitigating NAFLD by enhancing autophagy via PI3K/Akt/mTOR inhibition, reducing inflammation, and restoring gut microbiota balance, alongside activating the PDE4D/cAMP/PKA/CREB pathway to improve hepatic lipid metabolism and oxidative stress.

Cardiology Family Medicine & Nutrition news Specialties

Divergent Impacts of Low- and High-Protein Fasting-Mimicking Diets on Cardiometabolic Health and Autophagy

By MedXY 08/30/2025

A 7-day randomized study shows that both low- and high-protein fasting-mimicking diets improve cardiometabolic health and autophagy, with high-protein variants uniquely enhancing visceral fat reduction, lipid profiles, heart rate variability, and gut microbiome diversity.