antidepressants – Medxy AI

Decoding Antidepressant Response: Genetic and Phenotypic Markers of Treatment Complexity and Sustained Use

By MedXY 01/31/2026

A large-scale retrospective cohort study identifies specific phenotypic traits and genetic markers, including the SLAMF3/LY9 locus, that predict antidepressant treatment complexity and sustained use, offering a roadmap for precision psychiatry in managing major depressive disorder.

news Psychiatry

Slow Tapering with Psychological Support Matches Medication Continuation for Relapse Prevention in Remitted Depression

By MedXY 12/19/2025

A landmark network meta-analysis demonstrates that slow antidepressant tapering (>4 weeks) combined with psychological support is as effective as drug continuation in preventing relapse, providing a safe, evidence-based pathway for patients seeking to discontinue long-term treatment.

Cardiology news Psychiatry

Not All Antidepressants Are the Same: Differential Cardiometabolic and Physiological Effects from a Large Network Meta‑analysis

By MedXY 11/11/2025

A 151‑trial network meta‑analysis of 58,534 participants shows marked differences among 30 antidepressants in weight, blood pressure, heart rate, lipids, glucose and liver enzymes; findings support individualized choice and targeted baseline and follow‑up monitoring.

news Psychiatry

Evaluating Antidepressant Impact on Bipolar Depression: Insights from a Propensity Score Analysis in the STEP-BD Cohort

By MedXY 10/27/2025

A propensity score analysis of STEP-BD data reveals no significant association between antidepressant use and either manic switch risk or symptomatic remission in bipolar depression, highlighting the need for alternative treatment strategies.

Clinical Updates Psychiatry Public Health

Long-Term Exposure to Air Pollution and Road Traffic Noise: Associations with Antidepressant Medication Dispensing in Swedish Adults

By MedXY 10/23/2025

This review synthesizes evidence linking long-term air pollution and road traffic noise exposure with antidepressant medication dispensing, highlighting sex-specific associations and implications for mental health prevention strategies.

Medical News OB/GYN & Women's Health Psychiatry Specialties

FDA Panel Reviews SSRI Use During Pregnancy: Balancing Fetal Risks and Maternal Mental Health

By MedXY 07/29/2025

An FDA expert panel debates the risks and benefits of SSRI antidepressants in pregnancy, emphasizing the need to weigh untreated depression risks against potential drug-related fetal outcomes.

news OB/GYN & Women's Health Specialties

SSRIs and Pregnancy: Navigating the Risks, Benefits, and Ongoing Debate

By MedXY 07/29/2025

A new FDA panel reignites debate over the safety and efficacy of antidepressant use during pregnancy, with experts weighing in on emerging research and practice recommendations.