anesthesiology – Medxy AI

Wearable TEAS Device Outperforms Metoclopramide for Moderate to Severe Postoperative Nausea and Vomiting

By MedXY 01/31/2026

A randomized clinical trial demonstrates that wearable transcutaneous electrical acupoint stimulation (TEAS) provides superior symptom relief and significantly lower relapse rates compared to intravenous metoclopramide in managing moderate to severe postoperative nausea and vomiting.

Anesthesiology news Otorhinolaryngology

Optimizing the Surgical Field: Diltiazem and Esmolol Excel in Controlled Hypotension for Endoscopic Sinus Surgery

By MedXY 01/30/2026

This systematic review and network meta-analysis of 52 randomized trials evaluates pharmacological agents for controlled hypotension in ESS, identifying diltiazem, esmolol, and dexmedetomidine as the most effective for reducing intraoperative bleeding and improving surgical visualization.

Cardiology General Surgery news

Individualized Blood Pressure Targets vs. Standard Care: Insights from the IMPROVE-multi Trial

By MedXY 01/16/2026

The IMPROVE-multi trial found that targeting blood pressure based on preoperative nighttime levels did not reduce postoperative complications compared to a standard MAP target of 65 mm Hg in high-risk abdominal surgery patients.

Anesthesiology General Surgery news

Risk-Stratified Proactive Blood Pressure Management Fails to Improve Long-Term Functional Recovery After Noncardiac Surgery: Insights from the PRETREAT Trial

By MedXY 01/16/2026

The PRETREAT randomized clinical trial demonstrates that proactive, risk-stratified intraoperative blood pressure targets do not reduce six-month functional disability compared to standard care in noncardiac surgery patients, suggesting that higher MAP targets may not translate into long-term functional benefits.

Anesthesiology General Surgery news

Individualized Driving Pressure-Guided PEEP Fails to Reduce Pulmonary Complications in Open Abdominal Surgery: Results from the DESIGNATION Trial

By MedXY 12/28/2025

The DESIGNATION trial demonstrates that driving pressure-guided high PEEP with recruitment maneuvers does not reduce postoperative pulmonary complications compared to standard low PEEP in patients undergoing open abdominal surgery, while significantly increasing the risk of intraoperative hypotension and the need for vasoactive support.

Anesthesiology Critical Care news

Physiologic PK-PD Modeling Reveals Greater Fentanyl Potency for Ventilatory Depression Than Simpler Approaches

By MedXY 11/06/2025

A population PK–PD study in healthy volunteers found that a physiologic model incorporating CO2 kinetics and a ventilatory controller estimates fentanyl potency for ventilatory depression at ~2.3 ng/mL—substantially lower than estimates from simpler models, with implications for perioperative opioid safety and modeling methodology.