Posted inClinical Updates Neurology news Specialties
Trehalose in ALS: No Efficacy Shown in the HEALEY ALS Platform Trial
Trehalose was safe but did not slow ALS progression compared to placebo in a large, adaptive phase 2/3 trial.
Posted inClinical Updates news Oncology Specialties
Cancer Treatment and Genetic Predisposition Drive Subsequent Neoplasm Risk in Childhood Cancer Survivors
A comprehensive analysis reveals that radiotherapy, chemotherapy, and genetic factors substantially contribute to subsequent neoplasms in long-term childhood cancer survivors, while lifestyle factors play a minimal role.
Posted inClinical Updates news Oncology Specialties Urology
Enfortumab Vedotin Plus Pembrolizumab vs Chemotherapy in Untreated Locally Advanced or Metastatic Urothelial Cancer: Patient-Reported Outcomes from the EV-302 Phase 3 Study
The EV-302 trial shows enfortumab vedotin plus pembrolizumab improves survival and quality of life over platinum-based chemotherapy in untreated advanced urothelial cancer patients.
Posted inCardiology news Specialties
6 Behaviors That Seem to Cause Weight Gain but Actually Help with Weight Loss
Discover six surprising habits that help with weight loss, including eating moderate amounts of meat and snacks, avoiding strict carb elimination, drinking tea or low-calorie coffee, getting enough sleep, and eating right after exercise.
Posted inNeurology news Specialties
Understanding and Managing Alzheimer’s Disease: A Comprehensive Guide
An in-depth overview of Alzheimer's disease, covering its causes, symptoms, diagnosis, treatment options, and caregiving strategies.
Posted inCritical Care news Specialties
Memorize the “Anaphylactic Shock” Emergency Resuscitation Sequence to Easily Handle Critical Emergency Cases!
Severe allergic reaction refers to a sudden, severe, potentially life-threatening systemic allergic reaction in the…
Posted inInfectious Diseases news Specialties
Norfloxacin, Levofloxacin, Moxifloxacin: 3 Minutes to Understand the Differences, Misuse Harms Your Health!
"Take Norfloxacin for diarrhea, Levofloxacin for urinary tract infections, and Moxifloxacin for pneumonia" – this…
Dexamethasone: Essential Precautions and Key Drug Interactions to Know
Dexamethasone is a powerful corticosteroid that requires careful use due to potential harmful drug interactions and side effects. This article highlights crucial precautions and compatibility issues for safe administration.
Ibuprofen vs. Acetaminophen: Which Fever Reducer is Right for You?
Explore the differences, uses, and safety of ibuprofen and acetaminophen for managing fever effectively.
Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Haemoglobinuria: 48-Week Outcomes from APPLY-PNH and APPOINT-PNH Phase 3 Trials
Oral iptacopan provides sustained haemolysis control and improved haemoglobin in PNH patients over 48 weeks, with a favorable safety profile, supporting its role as a new therapeutic option.
Posted inClinical Updates news Rheumatology Specialties
Oral Regimens for Whipple’s Disease: A Non-Inferiority Trial of Doxycycline-Hydroxychloroquine Versus Standard Intravenous Therapy
A German phase 2/3 trial found oral doxycycline-hydroxychloroquine as effective and safe as standard intravenous ceftriaxone followed by oral trimethoprim-sulfamethoxazole for Whipple’s disease, potentially transforming outpatient management.
Dissecting Depression in Diabetes: Distinct Links of Somatic and Cognitive Symptoms with Inflammation and Insulin Resistance
New GRADE sub-study reveals that somatic symptoms of depression, not cognitive-affective symptoms, are chiefly associated with inflammation and insulin resistance in type 2 diabetes, highlighting a pathophysiological bridge for targeted interventions.
Seasonal Malaria Chemoprevention in Uganda: Efficacy of SPAQ and Dihydroartemisinin-Piperaquine in the Era of Drug Resistance
A large cluster-randomised trial in Uganda demonstrates that both SPAQ and dihydroartemisinin-piperaquine are highly effective and safe for seasonal malaria chemoprevention in children, with no evidence of resistance selection.
Posted inClinical Updates news Oncology Specialties
Selumetinib for Adults with NF1-Associated Inoperable Plexiform Neurofibromas: Results from the KOMET Phase 3 Trial
The KOMET phase 3 trial shows selumetinib offers significant tumor response in adults with NF1 and inoperable plexiform neurofibromas, with a manageable safety profile.
Relacorilant Plus Nab-Paclitaxel: A New Standard for Platinum-Resistant Ovarian Cancer?
Relacorilant combined with nab-paclitaxel significantly improved progression-free and overall survival in platinum-resistant ovarian cancer, with a favorable safety profile, suggesting a potential new treatment standard.
Posted inClinical Updates news Orthopedics Specialties
Surgery Versus Corticosteroid Injection for Carpal Tunnel Syndrome: Insights from the DISTRICTS Randomised Controlled Trial
The DISTRICTS trial demonstrates that initial surgical treatment for carpal tunnel syndrome leads to significantly higher recovery rates at 18 months compared to starting with corticosteroid injections, despite similar adverse event profiles.
Posted inClinical Updates news Oncology Specialties
Retifanlimab Plus Carboplatin-Paclitaxel: A New Standard for Advanced Squamous Cell Anal Cancer?
Retifanlimab combined with carboplatin-paclitaxel significantly prolongs progression-free survival in advanced squamous cell anal cancer, offering a promising new first-line standard of care.
Posted inClinical Updates news Oncology Specialties
First-Line Maintenance Therapy with Lurbinectedin Plus Atezolizumab in ES-SCLC: Clinical Impact of the IMforte Phase 3 Trial
The IMforte phase 3 trial demonstrates that lurbinectedin plus atezolizumab as first-line maintenance significantly prolongs progression-free and overall survival in extensive-stage small-cell lung cancer, albeit with increased hematologic toxicity.
Posted inAI Clinical Updates General Surgery news Specialties
Online Video Versus Face-to-Face Preoperative Consultation for Major Abdominal Surgery: Insights from the VIDEOGO Non-Inferiority Trial
The VIDEOGO trial shows that online video consultations are non-inferior to face-to-face consultations for preoperative assessment in major abdominal surgery, achieving similar patient satisfaction and information recall.
Targeted Pneumococcal Vaccination in New Older Adult Care Home Residents: Evidence from National Surveillance in England
Vaccinating new older adult care home residents with PCV20 or PPV23 could prevent substantially more invasive pneumococcal disease cases and deaths per dose than standard age-based vaccination, supporting policy revision.