Oncology – Page 27

Targeting Oxytocin Receptor: A Novel Strategy Against Hepatocellular Carcinoma Using Atosiban

By MedXY 08/31/2025

Recent research identifies the oxytocin receptor (OXTR) as a critical driver of liver cancer via Hippo/YAP signaling. The FDA-approved tocolytic drug Atosiban shows promise in blocking this pathway, offering new therapeutic avenues in hepatocellular carcinoma management.

news OB/GYN & Women's Health Oncology Specialties

Age-Dependent Survival Outcomes in Early-Stage Endometrial Cancer: Fertility-Preserving Hormonal Therapy Versus Hysterectomy

By MedXY 08/31/2025

Fertility-preserving hormonal therapy for early-stage endometrial cancer shows comparable 5-year survival to hysterectomy in women under 40, but a significantly higher mortality risk in those aged 40-49 years, highlighting age as a critical factor in treatment decisions.

news Oncology Pathology & Lab Medicine Specialties

Decoding Cancer Risk: Rare Pathogenic Variants and Their Role in Single and Multiple Cancer Diagnoses

By MedXY 08/31/2025

A large population-based genetic study clarifies the associations of rare pathogenic variants in established cancer predisposition genes with the risk of single and multiple primary cancers, supporting multigene panel testing in affected individuals.

news OB/GYN & Women's Health Oncology Specialties

Fertility-Preserving Hormonal Therapy vs Hysterectomy in Early-Stage Endometrial Cancer: Survival Outcomes and Clinical Implications

By MedXY 08/31/2025

This analysis compares survival in young women with early-stage endometrial cancer treated with fertility-preserving hormonal therapy versus hysterectomy, highlighting survival equivalence in women under 40 years and increased mortality risk in older patients undergoing hormonal therapy.

Medical News news Oncology Public Health Specialties

Persistent Medical Debt After Cancer Diagnosis: Insights from a Large Massachusetts Cohort Study

By MedXY 08/30/2025

A Massachusetts cohort study reveals modest but persistent increases in medical debt after cancer diagnosis, particularly in colorectal and bladder cancers, despite high insurance coverage. Total debt, bankruptcy rates, and credit scores remained largely unchanged in the overall population.

Allergy & Immunology Clinical Updates news Oncology Specialties

Tumor Microenvironment-Responsive Mn-Based Nanoplatform Activates cGAS-STING Pathway Coupled with Metabolic Interference for Enhanced Antitumor Therapy

By MedXY 08/30/2025

A novel Mn-based nanoplatform, LT@MnO@MON-HA (LMMH), responsive to tumor microenvironment triggers metabolic disruption and robust cGAS-STING activation, potentiating chemodynamic therapy and immunotherapy for improved tumor suppression.

Clinical Updates news Oncology Radiology Specialties

Real-time MRI Visualization of Tumor Acidosis: A Novel Predictor of Therapeutic Efficacy Using a Manganese Sulfide-Based Nanoplatform

By MedXY 08/30/2025

A manganese sulfide nanoplatform loaded with proton pump inhibitor enables real-time MRI visualization of tumor acidosis, providing early prediction of therapeutic efficacy and potential for improved cancer management.

Allergy & Immunology Clinical Updates news Oncology Specialties

Manganese: A Potent Catalyst Enhancing Cancer Immunotherapy

By MedXY 08/30/2025

Manganese and its nanoparticles play a pivotal role in cancer immunotherapy by modulating immune pathways, reshaping the tumor microenvironment, and serving as effective adjuvants and drug carriers, offering promising avenues to overcome current therapeutic challenges.

OB/GYN & Women's Health Oncology Specialties

ChatGPT-4o versus Gynecologic Oncologists in Endometrial Cancer Patient Communication: A Prospective Comparative Study

By MedXY 08/27/2025

This study compares ChatGPT-4o and gynecologic oncologists in addressing endometrial cancer patient questions, showing superior AI accuracy, empathy, and completeness, though lengthy responses may challenge patient comprehension.

Anesthesiology General Surgery news Nursing & care Oncology Specialties

Electroacupuncture Significantly Shortens Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer: Insights from a Multicenter Randomized Trial

By MedXY 08/26/2025

This multicenter randomized trial demonstrates that electroacupuncture reduces postoperative ileus duration and accelerates gastrointestinal recovery after laparoscopic gastrectomy for gastric cancer, outperforming sham and standard care.

Clinical Updates news Oncology Radiology Specialties

Optimizing Twice-Daily Thoracic Radiotherapy Dosage in Limited-Stage Small-Cell Lung Cancer: Impact on Survival and Toxicity

By MedXY 08/26/2025

A phase II trial reveals that high-dose twice-daily thoracic radiotherapy (60 Gy/40 fractions) significantly improves survival without increasing severe toxicity compared to the standard dose (45 Gy/30 fractions) in limited-stage SCLC patients.

Oncology Specialties

Extended Rivaroxaban Therapy in Cancer Patients with Low-Risk Pulmonary Embolism: 6 OR 18 Months？

By MedXY 08/26/2025

An 18-month course of rivaroxaban significantly lowers recurrent venous thromboembolism compared to 6 months in cancer patients with low-risk pulmonary embolism without a substantial increase in major bleeding risk.

Oncology Specialties

Anticoagulant therapy for cancer-associated splanchnic vein thrombosis: Outcomes during a one-year follow-up period

By MedXY 08/26/2025

This study evaluates one-year outcomes in cancer-associated splanchnic vein thrombosis, showing anticoagulation increases recanalization and bleeding risk but offers no survival benefit, highlighting tumor thrombus and metastasis as key mortality predictors.

Oncology Psychiatry Specialties

Reducing Carcinogen Exposure in Smokers with Serious Mental Illness: Insights from a Randomized Controlled Trial of E-Cigarette Provision

By MedXY 08/25/2025

This RCT demonstrates that disposable e-cigarettes significantly reduce carcinogen levels short-term among smokers with serious mental illness, underscoring the need for behavioral support to sustain harm reduction.

Oncology Psychiatry Specialties

Esketamine in Lung Cancer Patients with Major Depression: Efficacy for Smoking Cessation and Treatment-Resistant Depression

By MedXY 08/25/2025

This review synthesizes evidence from a randomized trial and real-world studies showing esketamine's efficacy and safety in smoking cessation among lung cancer patients with MDD, as well as in treatment-resistant depression, highlighting cognitive benefits and long-term safety.

news Oncology Public Health Specialties

International Trends in Biliary Tract Cancer Mortality from 2000 to 2022: A Comprehensive WHO Database Analysis

By MedXY 08/25/2025

This observational study reveals stable global biliary tract cancer mortality rates over two decades, with a striking rise in intrahepatic cholangiocarcinoma mortality, underscoring the need for targeted screening and management strategies.

Clinical Updates Family Medicine & Nutrition news Oncology Specialties

Live Music Therapy in Advanced Cancer: Efficacy in Pain and Symptom Relief Confirmed by MSPD Pilot Study and Meta-Analysis

By MedXY 08/25/2025

A single session of live music therapy significantly reduced pain, fatigue, and anxiety in advanced cancer patients, with high patient satisfaction. These findings align with meta-analytic evidence supporting music therapy's benefits in oncology.

Clinical Updates Gastroenterology news Oncology Specialties

Pathobionts in Colorectal Tumour Microbiota: Predicting Survival and Shaping Oncological Outcomes

By MedXY 08/24/2025

This study identifies specific pathobiont bacterial clusters in colorectal tumour microbiota that predict disease-free survival post-surgical resection, linking microbial and metabolic profiles to colorectal cancer prognosis.

Family Medicine & Nutrition Medical News news Oncology Specialties

Understanding Breast Cancer Risk: Habits and Genetic Factors That Quietly Increase Danger

By MedXY 08/23/2025

Breast cancer is the most common cancer among women, with 90% of patients belonging to high-risk groups. This article explores five major risk factors, early detection strategies, and lifestyle changes crucial for prevention.

Clinical Updates Family Medicine & Nutrition Gastroenterology news Oncology Specialties

Butyrate-Producing Clostridium butyricum: A Direct Interactor with Colorectal Cancer Cells that Reverses Immune Suppression and Enhances Checkpoint Inhibitor Efficacy

By MedXY 08/23/2025

Recent research uncovers that the probiotic Clostridium butyricum directly interacts with colorectal cancer cells to inhibit immune suppression via the secD-GRP78 axis, restoring CD8+ T cell antitumor function and enhancing PD-1 inhibitor therapy.