Urgent Surgery Versus Fibrinolytic Therapy in Left-Sided Prosthetic Valve Thrombosis: Insights from a Groundbreaking Randomized Trial

Urgent Surgery Versus Fibrinolytic Therapy in Left-Sided Prosthetic Valve Thrombosis: Insights from a Groundbreaking Randomized Trial

This first randomized trial comparing urgent surgery and fibrinolytic therapy (low-dose t-PA) for symptomatic left-sided prosthetic valve thrombosis finds similar efficacy but higher mortality with surgery and higher residual valve dysfunction with fibrinolysis.
Reevaluating Early Blood Pressure Targets in Acute Spinal Cord Injury: Insights from a Multicenter Randomized Trial

Reevaluating Early Blood Pressure Targets in Acute Spinal Cord Injury: Insights from a Multicenter Randomized Trial

A recent randomized clinical trial comparing augmented to conventional blood pressure targets in acute spinal cord injury found no improvement in 6-month neurological outcomes, challenging current practices and highlighting risks of higher blood pressure management.
Parecoxib and Imrecoxib Sequential Therapy: A Breakthrough in Managing Severe Acute Pancreatitis

Parecoxib and Imrecoxib Sequential Therapy: A Breakthrough in Managing Severe Acute Pancreatitis

This multicentre trial shows sequential use of COX-2 inhibitors parecoxib and imrecoxib significantly reduces severe acute pancreatitis (SAP) incidence, shortens organ failure duration, lowers local complications, and decreases 30-day mortality, with a good safety profile.