Clinical Updates – Page 29

M72/AS01E-4 Tuberculosis Vaccine: Promising Advances for HIV-Positive Populations in High-Burden Settings

By MedXY 08/05/2025

A phase 2 trial in South Africa shows that the M72/AS01E-4 TB vaccine is safe and immunogenic for virally suppressed, ART-treated HIV-positive adolescents and adults, supporting its potential to address a key unmet clinical need.

Allergy & Immunology Clinical Updates Neurology news Specialties

Psychedelics Target Neuroimmune Interactions to Limit Fear

By MedXY 08/05/2025

Research reveals how psychedelics modulate immune-to-brain communication to reduce fear, offering new therapeutic avenues for stress-related psychiatric disorders.

Clinical Updates news Orthopedics Specialties

Exercise Alone Matches Diet Plus Exercise for Hip Osteoarthritis Pain Relief, Large Randomized Trial Shows

By MedXY 08/04/2025

Adding a very-low-calorie diet to exercise yields no additional pain relief for overweight or obese adults with hip osteoarthritis, despite greater weight loss.

AI Clinical Updates news Specialties

Artificial Intelligence in Clinical Trials: Building a Value-Based Framework for Effective Adoption

By MedXY 08/04/2025

AI offers transformative potential for clinical trials, but realizing its value demands a robust, stakeholder-driven framework to guide adoption and assess impact across the trial lifecycle.

AI Clinical Updates news OB/GYN & Women's Health Specialties

Evaluation of ChatGPT-4 as an Online Outpatient Assistant in Puerperal Mastitis Management: An Observational Study Analysis

By MedXY 08/04/2025

This study assesses ChatGPT-4's effectiveness as a virtual assistant in managing puerperal mastitis, focusing on accuracy, clarity, and safety in patient communication.

Clinical Updates news Pediatrics Specialties

Darbepoetin in Preterm Infants: Enhancing Red Cell Mass without Neurodevelopmental Benefit

By MedXY 08/04/2025

Weekly darbepoetin in extremely preterm infants increases red cell mass and reduces transfusion needs, but does not improve cognitive outcomes at 22-26 months' corrected age.

Clinical Updates news Psychiatry Specialties

Do Safety Planning Interventions Reduce Suicide Risk in Adolescents? Insights from a Systematic Review and Meta-Analysis

By MedXY 08/04/2025

Recent meta-analysis finds no significant benefit of standalone safety planning interventions in reducing suicidal ideation or behavior among adolescents, highlighting the need for more robust research.

Allergy & Immunology Clinical Updates Neurology news Psychiatry Respiratory Specialties

Empowering Parents: Acceptance and Commitment Therapy for Children With Asthma and ADHD

By MedXY 08/04/2025

A randomized clinical trial demonstrates that an Acceptance and Commitment Therapy-based parenting program reduces health care use, improves asthma control, and alleviates ADHD symptoms in children with both conditions.

Cardiology Clinical Updates news Specialties

DASH4D Trial: Dietary Patterns and Sodium Reduction for Blood Pressure Control in Type 2 Diabetes

By MedXY 08/04/2025

The DASH4D trial demonstrates that sodium reduction, alongside a tailored DASH diet, significantly lowers blood pressure in adults with type 2 diabetes, most of whom already use multiple antihypertensive medications.

Clinical Updates Critical Care news Nursing & care Pediatrics Specialties

Intensive Nurse Home Visiting and Early Childhood Outcomes: A Randomized Clinical Trial

By MedXY 08/04/2025

A randomized trial assessing the impact of Nurse-Family Partnership home visits on child health and utilization over two years found no significant reduction in adverse outcomes but some decrease in emergency department use.

Cardiology Clinical Updates Specialties

Heart Failure Risk with Pregabalin vs Gabapentin: New Evidence for Chronic Pain Management in Older Adults

By MedXY 08/04/2025

New data show an increased risk of heart failure among elderly Medicare patients initiating pregabalin versus gabapentin for chronic noncancer pain, particularly in those with cardiovascular disease history.

Clinical Updates Family Medicine & Nutrition Neurology Specialties

Regulation of Cues vs Cognitive Behavioral Therapy: Advancing Binge Eating Disorder Treatment for Veterans

By MedXY 08/04/2025

ROC plus behavioral weight loss outperformed CBT in reducing binge eating among veterans, with transient advantages in weight loss. Long-term weight outcomes require further research.

Allergy & Immunology Clinical Updates news Rheumatology Specialties

Therapeutic Strategies for Disease-Modifying Therapy Management in Pregnant Women With Multiple Sclerosis: Relapse Risk and Clinical Implications

By MedXY 08/04/2025

Managing disease-modifying therapies (DMTs) during pregnancy in women with multiple sclerosis significantly affects relapse risk, with anti-CD20 strategies demonstrating superior protection compared to other approaches.

Clinical Updates Family Medicine & Nutrition news Pediatrics Specialties

Supplemental Donor Milk versus Infant Formula for Moderate to Late Preterm Infants: Implications from a Multisite Randomized Trial

By MedXY 08/04/2025

A multisite RCT found no difference in time to full enteral feeds between donor human milk and formula in moderate to late preterm infants, but formula was associated with faster weight regain.

Clinical Updates news Oncology Specialties

Cannabis Use Disorder Linked to Elevated Risk of Benign Salivary Gland Tumors: New Insights from a Large Retrospective Cohort Study

By MedXY 08/04/2025

A large US-based study found a greater than fivefold increased risk of benign salivary gland tumors, especially parotid tumors, in individuals with cannabis use disorder.

Clinical Updates news Pediatrics Specialties

Does Treating Older Siblings Enhance the Impact of Azithromycin on Infant Survival? Insights from a Cluster-Randomized Trial in Niger

By MedXY 08/04/2025

Mass azithromycin administration to both infants and older children reduced infant mortality more than treating infants alone, with potential spillover benefits from treating older siblings.

Clinical Updates news

Optimizing Daptomycin Use in Japanese Pediatric Patients: The Critical Roles of Dose and Renal Function

By MedXY 08/04/2025

A multicenter study in Japan found that adequate daptomycin dosing significantly improves clinical outcomes in pediatric patients, while adverse events can occur regardless of renal function.

Clinical Updates news

Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation

By MedXY 08/04/2025

Perinatal antibiotic exposure in preterm infants disrupts gut microbiota composition, increasing pathogenic bacteria and reducing beneficial species, with implications for infection risk and the protective role of breastfeeding.

Clinical Updates news

Disparities in Inpatient Antibiotic Use for Pediatric Pneumonia: Minority and Low-Opportunity Children at Higher Risk of Overtreatment

By MedXY 08/04/2025

Minority children and those from lower socioeconomic backgrounds receive significantly more and broader-spectrum antibiotics for pneumonia during hospitalization than non-Hispanic White counterparts, contrary to outpatient trends.

Clinical Updates news Oncology Specialties

A Century of Change: How Human Innovation Transformed Lung Cancer Treatment

By MedXY 08/03/2025

Lung cancer therapy has evolved from rudimentary surgery and misdiagnosis to a precision medicine era, markedly improving outcomes through targeted therapies and immunotherapy.