Optimizing Empiric Antibiotic Selection in Hospitalized Patients with Skin and Abdominal Infections: Insights from the INSPIRE 3 and 4 Cluster Randomized Clinical Trials
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Optimizing Empiric Antibiotic Selection in Hospitalized Patients with Skin and Abdominal Infections: Insights from the INSPIRE 3 and 4 Cluster Randomized Clinical Trials

The INSPIRE 3 and 4 trials demonstrate that computerized provider order entry (CPOE) prompts with patient-specific MDRO risk estimates, combined with education and feedback, significantly reduce empiric extended-spectrum antibiotic use in skin, soft tissue, and abdominal infections without compromising safety.