Specialties – Page 74

Aspirin vs. Clopidogrel Monotherapy Following PCI: Insights from the STOPDAPT-3 1-Year Follow-up

By MedXY 09/22/2025

The STOPDAPT-3 trial compared aspirin and clopidogrel monotherapy after short dual antiplatelet therapy in PCI patients, showing similar cardiovascular and bleeding outcomes at 1 year.

Cardiology Clinical Updates news Specialties

Aspirin-Free Strategy in High Bleeding Risk PCI Patients: Insights from STOPDAPT-3 Subgroup Analysis

By MedXY 09/22/2025

In high bleeding risk patients undergoing PCI, aspirin-free prasugrel monotherapy fails to reduce major bleeding and shows increased myocardial infarction risk in ACS but not non-ACS patients, suggesting selective use post-PCI.

Cardiology Clinical Updates Radiology

Comparing Cardiac MRI and Coronary Angiography for Diagnosing Ischemic Cardiomyopathy in New-Onset Heart Failure

By MedXY 09/22/2025

A multicenter trial shows cardiac MRI offers comparable sensitivity to invasive coronary angiography for diagnosing ischemic cardiomyopathy, reducing invasive procedures in newly diagnosed heart failure patients.

Clinical Updates Neurology OB/GYN & Women's Health

Intranasal Mesenchymal Stromal Cells for Perinatal Arterial Stroke: Promising Safety and Improved Neurodevelopment at Two Years

By MedXY 09/22/2025

The PASSIoN study shows that intranasally administered allogeneic mesenchymal stromal cells in neonates with perinatal arterial ischemic stroke are safe up to two years and suggest better motor outcomes compared to untreated cohorts.

Clinical Updates Neurology

RNS60 as Adjunctive Therapy in Acute Large Vessel Occlusion Stroke: Insights from the RESCUE Trial

By MedXY 09/22/2025

The RESCUE trial demonstrates that RNS60, a novel oxygen-supersaturated saline solution, is safe and reduces infarct growth when added to endovascular thrombectomy in acute ischemic stroke due to large vessel occlusion, supporting further investigation in larger studies.

Cardiology Clinical Updates Critical Care news Specialties

Advanced Airway Devices and End-Tidal CO2 Trends in Cardiac Arrest: Insights from a Multicenter Randomized Trial

By MedXY 09/22/2025

This analysis compares end-tidal CO2 trends between laryngeal tube and endotracheal intubation in out-of-hospital cardiac arrest, revealing no significant difference in absolute values but highlighting complex interactions affecting return of spontaneous circulation outcomes.

Cardiology

Aspirin Versus Clopidogrel After Acute Coronary Syndrome: Insights from STOPDAPT-3 in High-Bleeding Risk and STEMI Patients

By MedXY 09/22/2025

STOPDAPT-3 trial shows aspirin and clopidogrel yield comparable cardiovascular and bleeding outcomes 1 month to 1 year post-PCI in ACS patients, regardless of bleeding risk or STEMI status.

Clinical Updates Emergency Medicine General Surgery news

Urgent Surgery Versus Fibrinolytic Therapy in Left-Sided Prosthetic Valve Thrombosis: Insights from a Groundbreaking Randomized Trial

By MedXY 09/22/2025

This first randomized trial comparing urgent surgery and fibrinolytic therapy (low-dose t-PA) for symptomatic left-sided prosthetic valve thrombosis finds similar efficacy but higher mortality with surgery and higher residual valve dysfunction with fibrinolysis.

Cardiology Clinical Updates news

Intravascular Imaging-Guided PCI vs CABG for Left Main or 3-Vessel Disease: Bridging the Outcome Gap

By MedXY 09/22/2025

Recent study shows intravascular imaging-guided PCI may offer comparable 3-year outcomes to CABG in patients with left main or 3-vessel coronary disease, challenging prior assumptions favoring surgery.

Clinical Updates Neurology news

Safety and Efficacy of Perispinal Etanercept for Chronic Stroke: A Comprehensive Review of Clinical Trial Evidence

By MedXY 09/22/2025

Perispinal etanercept is safe but does not improve quality of life in chronic stroke patients, as demonstrated by a Class I randomized trial; translational implications and future research directions are discussed.

Anesthesiology General Surgery news Specialties

Intensive vs Conventional Intraoperative Blood Pressure Management: Insights from the BP-CARES Trial on Cardiovascular Outcomes After Major Abdominal Surgery

By MedXY 09/22/2025

The BP-CARES randomized trial found no cardiovascular benefit of intensive intraoperative blood pressure management (MAP ≥80 mm Hg) over conventional targets in high-risk major abdominal surgery patients.

Clinical Updates Neurology news Ophthalmology

Evaluating Visual Scanning Training for Post-Stroke Homonymous Hemianopia: Insights from the SEARCH Trial

By MedXY 09/22/2025

The SEARCH trial investigated visual scanning training versus sham therapy in stroke survivors with homonymous hemianopia, finding no significant difference yet highlighting potential placebo and clinician-engagement effects, informing future rehabilitation approaches.

Cardiology Clinical Updates Neurology news Specialties

Impact of Hypertension History on the Efficacy of Clopidogrel-Aspirin Therapy in Ischemic Stroke Prevention

By MedXY 09/22/2025

This study investigates how a history of hypertension influences the effectiveness of combined clopidogrel-aspirin treatment in preventing recurrent strokes after mild ischemic events or high-risk transient ischemic attacks.

Clinical Updates Diabetes & Endocrinology Neurology news Specialties

Long-term Stroke Risk in Chinese Adults with Newly Diagnosed Diabetes and Impaired Glucose Tolerance: Insights from the 34-Year Da Qing Diabetes Study

By MedXY 09/22/2025

A 34-year follow-up of the Da Qing Diabetes Study reveals significantly increased stroke incidence among Chinese adults with newly diagnosed type 2 diabetes and impaired glucose tolerance, highlighting the beneficial impact of lifestyle intervention, particularly in women.

Cardiology Clinical Updates news Specialties

DIALIZE-Outcomes Trial: Sodium Zirconium Cyclosilicate Effect on Cardiovascular Outcomes in Hemodialysis Patients with Hyperkalemia

By MedXY 09/22/2025

The DIALIZE-Outcomes trial assessed sodium zirconium cyclosilicate (SZC) in controlling predialysis hyperkalemia among hemodialysis patients but found no reduction in arrhythmia-related cardiovascular events despite improved potassium control.

Cardiology Clinical Updates news Specialties

Rivaroxaban vs Warfarin in Postcardiac Surgery Atrial Fibrillation: Insights from the NEW-AF Trial

By MedXY 09/22/2025

The NEW-AF trial compared rivaroxaban and warfarin in new-onset atrial fibrillation after cardiac surgery, finding no difference in length of hospital stay but greater patient convenience and similar safety with rivaroxaban.

Clinical Updates Neurology news Nursing & care Specialties

Dissecting the Care Bundle: Mediation Analysis of Key Components Driving Improved Outcomes in INTERACT3 for Acute Intracerebral Hemorrhage

By MedXY 09/22/2025

Mediation analysis of INTERACT3 reveals that systolic blood pressure and blood glucose control are primary drivers of functional recovery benefits in acute intracerebral hemorrhage care bundles.

Clinical Updates news Public Health

Immunogenicity and Safety of the VLA15 Lyme Borreliosis Vaccine Across Age Groups: A Phase 2 Randomised Controlled Trial and Integrative Review

By MedXY 09/21/2025

This review synthesizes data on the VLA15 Lyme borreliosis vaccine candidate, demonstrating its safety and robust immunogenicity in adults, adolescents, and children, supporting multi-dose schedules and highlighting enhanced antibody responses in pediatric populations.

Respiratory Specialties

MACRO Trial Insights: Endoscopic Sinus Surgery Outperforms Clarithromycin in Chronic Rhinosinusitis Management

By MedXY 09/21/2025

The MACRO trial demonstrates that endoscopic sinus surgery significantly improves quality of life in adults with chronic rhinosinusitis, while long-term low-dose clarithromycin shows no added benefit over placebo.

Clinical Updates HIV/AIDS news Respiratory

Adjunctive Corticosteroids in Severe Pneumocystis jirovecii Pneumonia Among HIV-negative Patients: Insights from a Multicentre Randomised Trial

By MedXY 09/21/2025

A multicentre randomized trial evaluated adjunctive corticosteroids in HIV-negative severe Pneumocystis jirovecii pneumonia, showing a non-significant reduction in 28-day mortality and no safety concerns, and calls for further targeted research.