Introduction
Every year, millions suffer from ischemic strokes and transient ischemic attacks (TIA), potentially life-altering cerebrovascular events. One often overlooked yet critical factor linked to poor recovery after these events is obstructive sleep apnea (OSA). OSA, a condition wherein breathing repeatedly stops and starts during sleep due to airway obstruction, is surprisingly common among stroke and TIA survivors. However, despite guidelines encouraging OSA testing in these patients, diagnosis rates remain low, delaying crucial treatment.
This article explores a cutting-edge quality improvement intervention aimed at boosting OSA diagnostic testing after stroke and TIA within the U.S. Department of Veterans Affairs (VA) hospitals. We will delve into the study design, outcomes, clinical implications, and practical lessons for improving care delivery.
Understanding Sleep Apnea and Its Link to Cerebrovascular Events
Obstructive sleep apnea involves repeated episodes of partial or complete blockage of the upper airway during sleep, causing reduced oxygen levels and fragmented sleep. This leads to increased sympathetic nervous system activity, hypertension, inflammation, and vascular stress, all contributing to stroke risk.
Studies have demonstrated the high prevalence of OSA among patients who have experienced ischemic stroke or TIA, with estimates reaching over 60%. Untreated OSA not only elevates the risk of recurrent strokes but also negatively affects functional recovery, cognition, and overall quality of life.
Despite these risks, many stroke and TIA patients do not undergo formal sleep apnea evaluation after their cerebrovascular event. Barriers include unawareness among providers, resource constraints, and complexity in arranging diagnostic testing.
The Quality Improvement Trial: A Closer Look
To address these gaps, Bravata et al. conducted a cluster randomized stepped-wedge trial from 2019 to 2024 across the VA healthcare system. This design involved rolling out a multi-component quality improvement intervention sequentially to clusters (hospital sites), allowing comparison between intervention and usual care periods.
The intervention included virtual kickoffs where site teams reviewed baseline data and devised tailored action plans to improve OSA testing rates. Monthly collaborative conferences fostered shared learning, supported by a web-based platform offering quality data tracking, educational resources, and expert facilitation.
Key Findings: Significant Uptake in OSA Testing and Treatment
The trial included 1747 patients at six intervention sites and 7454 patients at 30 usual care sites. The intervention dramatically increased 30-day OSA diagnostic testing rates from a mere 2.1% at baseline to 29.1% during implementation at intervention sites. In comparison, diagnostic rates at control sites remained stagnant between 0.7% and 2.2%.
Similarly, positive airway pressure (PAP) therapy initiation within 30 days improved from 0.3% to 2.8% at intervention sites, a substantial gain relative to minimal changes at control sites.
While the intervention did not statistically reduce 90-day hospital readmissions or recurrent vascular events during the study period, the increased accessibility of sleep apnea diagnosis and early treatment initiation represents an important step forward.
From Evidence to Action: Why This Matters
This study underscores the feasibility and effectiveness of structured quality improvement initiatives in translating clinical guidelines into practice. Engaging multidisciplinary teams, leveraging data transparency, and providing ongoing support enabled meaningful practice change within complex healthcare settings.
Patients like James, a 68-year-old stroke survivor, exemplify the potential benefits. Before the intervention, he might have left the hospital without sleep apnea evaluation despite symptoms like daytime fatigue and snoring. Thanks to the improved protocols, James underwent timely sleep testing, began PAP therapy, and is now on a better path to preventing stroke recurrence.
Practical Recommendations for Clinicians and Healthcare Systems
– Routinely screen all patients post-stroke or TIA for OSA symptoms or risk factors.
– Collaborate across neurology, sleep medicine, nursing, and rehabilitation teams to streamline pathways for sleep apnea diagnostic testing.
– Utilize virtual meetings and data dashboards to monitor performance and share best practices.
– Address local barriers such as staff training, patient education, and access to sleep studies.
Expert Insights
Dr. Deborah Bravata, lead investigator, highlighted, “By actively engaging frontline providers and leadership through customized plans and data transparency, we demonstrated that sustainable improvements in OSA testing are achievable even in large healthcare systems.” She emphasized that inpatient sleep medicine services integrated with stroke care are crucial for improving long-term outcomes.
Challenges and Future Directions
Despite progress, challenges remain in extending testing to underserved populations, ensuring patient adherence to PAP therapy, and demonstrating long-term reductions in stroke recurrence.
Future research should focus on refined strategies to enhance patient engagement, cost-effectiveness analyses, and integration of emerging technologies like home sleep apnea testing.
Conclusion
Obstructive sleep apnea is a common and modifiable risk factor jeopardizing recovery after ischemic stroke and TIA. This landmark quality improvement trial by the VA system exemplifies how targeted, collaborative efforts can markedly increase OSA diagnostic testing and treatment initiation.
By adopting similar approaches, healthcare systems nationwide can bridge the gap between guidelines and practice, ultimately improving cerebrovascular patient outcomes and quality of life.
Funding and Clinical Trial Registration
This research was supported by the Department of Veterans Affairs. The trial is registered at ClinicalTrials.gov (Identifier: NCT04322162).
References
Bravata DM, Perkins AJ, Myers LJ, Daggy JK, Sexson A, Taylor SE, Burrone L, Koo BB, Miech EJ, Rattray N, Story KM, Waddell KJ, Ding QP, Sico JJ; ASAP Investigators Group. Quality Improvement Intervention to Increase Sleep Apnea Diagnostic Testing After Stroke and Transient Ischemic Attack: A Cluster Randomized Trial. JAMA Netw Open. 2025 Nov 3;8(11):e2543385. doi: 10.1001/jamanetworkopen.2025.43385. PMID: 41236739; PMCID: PMC12619104.
