Clinical Updates – Page 14

Influenza-Associated Acute Necrotizing Encephalopathy in US Children

By MedXY 07/30/2025

A multicenter US study highlights the devastating burden of influenza-associated acute necrotizing encephalopathy in children, with high mortality and disability rates despite aggressive therapy, underscoring the urgent need for prevention and standardized management.

Clinical Updates Wellness & Lifestyle

Low Lupus Activity as a Predictive Target in Lupus Nephritis: A Clinical Appraisal of LLDAS

By MedXY 07/30/2025

Achieving low lupus disease activity (LLDAS) at 12 months is an attainable target in lupus nephritis and independently predicts reduced relapse risk and preserved renal function, supporting its potential as a future treatment goal.

Clinical Updates Wellness & Lifestyle

FDA Fast-Tracks Rezpegaldesleukin for Severe Alopecia Areata: Promise for a Challenging Disease

By MedXY 07/30/2025

The FDA has granted Fast Track status to rezpegaldesleukin (REZPEG), a novel biologic targeting regulatory T cells, for severe-to-very severe alopecia areata in patients aged ≥12 years. Phase 2b trial results are anticipated in December 2025.

Clinical Updates Wellness & Lifestyle

GLP-1 Receptor Agonists Linked to Early Risk of Optic Nerve Damage: A Case-Control Study Analysis

By MedXY 07/30/2025

GLP-1 receptor agonist use, especially liraglutide, is associated with a higher risk of nonarteritic anterior ischemic optic neuropathy (NAION) during the first year, particularly in patients without diabetes or obesity.

Clinical Updates Wellness & Lifestyle

Walking and Dietary Interventions Offer Cognitive Protection in APOE ε4 Carriers: New Evidence from Longitudinal and Multinational Trials

By MedXY 07/30/2025

Regular walking and lifestyle interventions slow cognitive decline, especially in APOE ε4 carriers at heightened Alzheimer’s risk, with effects pronounced in women. Evidence underscores the value of simple activity and healthy diet for at-risk older adults.

Clinical Updates Wellness & Lifestyle

Personal and Household Pesticide Exposure Linked to Increased Risk of Rheumatoid Arthritis in Female Farm Spouses

By MedXY 07/30/2025

New evidence links direct and indirect exposure to specific agricultural pesticides with increased risk of incident rheumatoid arthritis among female spouses of licensed pesticide applicators.

Clinical Updates Wellness & Lifestyle

Cockroach Immunotherapy Modulates Key T-Cell Responses Regardless of Allergen Extract Abundance

By MedXY 07/30/2025

A randomized trial finds that subcutaneous cockroach immunotherapy effectively downregulates dominant T-cell responses in pediatric asthma, independent of allergen abundance in the therapeutic extract.

Clinical Updates Wellness & Lifestyle

Muscle Strength as a Key Determinant of Metabolic Risk in Paediatric Obesity: New Evidence from Milan

By MedXY 07/30/2025

Stronger leg muscles are linked to significantly lower risk of metabolic syndrome in children and adolescents with obesity, highlighting the importance of muscular fitness in paediatric metabolic health.

Clinical Updates Wellness & Lifestyle

Evolving Patterns in Antiseizure Drug Use During Pregnancy: Safer Choices and New Uncertainties

By MedXY 07/30/2025

A decade-long French study reveals declining prenatal exposure to high-risk antiseizure drugs, increased use of safer alternatives, and a notable rise in prescriptions for newer drugs with uncertain safety profiles.

Clinical Updates Wellness & Lifestyle

Digital Self-Management Tools Enhance Asthma Control

By MedXY 07/30/2025

A randomized trial shows that a smartphone-based asthma self-management program improves symptom control in adults, though its effectiveness is attenuated in African American participants.