Clinical Updates – Page 2

$Phase Ib Trial of Metformin Combined with Nivolumab in Refractory Solid Tumors: Safety, Dosage, and Preliminary Efficacy$

Clinical Updates Wellness & Lifestyle

Phase Ib Trial of Metformin Combined with Nivolumab in Refractory Solid Tumors: Safety, Dosage, and Preliminary Efficacy

By MedXY 09/15/2025

A phase Ib study evaluated the safety, optimal dosing, pharmacokinetics, and preliminary efficacy of metformin with nivolumab in refractory solid tumors, showing good tolerability and promising responses in a subset of patients.

Clinical Updates Wellness & Lifestyle

Oral Metformin in Non-Muscle-Invasive Bladder Cancer: Insights from a Phase II Marker Lesion Study

By MedXY 09/15/2025

A phase II trial assessing oral metformin for low-grade non-muscle-invasive bladder cancer (NMIBC) found minimal antitumor activity and no significant mechanistic changes, challenging metformin’s role as an intravesical therapeutic agent in this context.

Clinical Updates Wellness & Lifestyle

Optimizing Anesthesia in Elderly NSCLC Patients: Impact of Midazolam and Dexmedetomidine Co-Administration on Hemodynamics and Stress Response

By MedXY 09/15/2025

Co-administering midazolam with dexmedetomidine in elderly NSCLC patients undergoing lobectomy enhances hemodynamic stability and reduces perioperative stress response, potentially improving recovery outcomes without increasing adverse events.

Clinical Updates Wellness & Lifestyle

Enhanced Gait Rehabilitation in Chronic Stroke: Combining High-Intensity Interval Training with Robot-Assisted Gait Therapy

By MedXY 09/14/2025

A randomized controlled trial demonstrates that combining high-intensity interval training with robot-assisted gait therapy significantly improves gait speed, balance, and lower limb function in patients with chronic stroke compared to treadmill therapy alone.

Clinical Updates Wellness & Lifestyle

Enhanced Adenoma Detection in Water Exchange Colonoscopy Using AI: Insights from a Two-Center Randomized Trial

By MedXY 09/14/2025

A multicenter trial demonstrated that integrating AI-based computer-aided detection with water exchange colonoscopy significantly increases adenomas per colonoscopy without prolonging procedure time or increasing non-neoplastic lesion detection.

Clinical Updates Wellness & Lifestyle

Advancing Clinical Care with AI Agents: Systematic Review of Performance and Integration in Medicine

By MedXY 09/14/2025

This review evaluates AI agent systems built on large language models in healthcare, demonstrating improved clinical task accuracy over base models, especially in complex scenarios. Multi-agent architectures show promise but require further real-world validation.

Clinical Updates Wellness & Lifestyle

Evaluating AI-Enhanced EMG Reporting: Insights from a Randomized Controlled Trial

By MedXY 09/14/2025

An RCT evaluated an AI-assisted framework for electrodiagnostic report interpretation, finding no significant improvement over standard physician reporting but highlighting potential workflow benefits for routine cases.

Clinical Updates Wellness & Lifestyle

Harnessing AI for Personalized Depression Treatment: Insights from the AID-ME Cluster Randomized Trial

By MedXY 09/14/2025

The AID-ME trial demonstrates that an AI-powered clinical decision support system significantly improves remission rates and accelerates symptom improvement in moderate to severe major depressive disorder.

Clinical Updates Wellness & Lifestyle

Unraveling the Complexity of Lung Cancer Screening: Comparative Insights from Two Landmark Trials

By MedXY 09/14/2025

Lung cancer screening reduces mortality but varies by risk factors, sex, and cancer histology. Analysis of NELSON and NLST trials highlights histology-driven heterogeneity and suggests broader screening criteria may improve outcomes.

Clinical Updates Wellness & Lifestyle

Evaluating Diagnocat AI: Accuracy in Detecting Periapical Radiolucencies on CBCT Scans of Molars

By MedXY 09/14/2025

A study assessing the AI-based platform Diagnocat reveals high sensitivity but moderate specificity in detecting periapical radiolucencies on CBCT scans of non-root-filled molars, with decreased accuracy post-root treatment, underscoring the need for clinician oversight.