Clinical Updates – Medxy AI

Early-Life Blueberry Consumption: Potential Benefits for Infant Allergy Resolution, Immune Modulation, and Gut Microbiome Development

By MedXY 09/16/2025

Daily blueberry intake during complementary feeding may enhance allergy symptom resolution, favorably influence immune biomarkers, and promote beneficial gut microbiota shifts in breastfed infants, suggesting new avenues for allergy prevention.

Clinical Updates Wellness & Lifestyle

Unlocking Better Sleep: How Daily Walnut Consumption Enhances Melatonin Metabolism and Sleep Quality in Young Adults

By MedXY 09/16/2025

A randomized crossover trial shows that daily intake of 40 g walnuts increases urinary 6-sulfatoxymelatonin, reduces sleep latency, and improves global sleep quality in young adults, highlighting walnuts' potential as a natural sleep aid.

Clinical Updates Wellness & Lifestyle

Enhanced Therapeutic Benefits of Combined Metformin and Curcumin in Women with Polycystic Ovary Syndrome: Results from a Factorial Clinical Trial

By MedXY 09/16/2025

A 12-week randomized trial demonstrates that combining metformin and nanocurcumin significantly improves lipid metabolism, glucose regulation, hormonal balance, and body metrics in women with PCOS, surpassing effects seen with either agent alone or placebo.

Clinical Updates Wellness & Lifestyle

Metformin with or without Mediterranean Diet Significantly Reduces Diabetes Risk in Metabolic Syndrome: Insights from the MeMeMe Trial

By MedXY 09/16/2025

The MeMeMe randomized trial shows that metformin 1,700 mg/day effectively prevents type 2 diabetes in metabolic syndrome patients, independent of Mediterranean diet adherence, with implications for age-related disease prevention.

Clinical Updates Wellness & Lifestyle

Innovative Combination Therapy in Recurrent Advanced Endometrial Cancer: Insights from the ENDOLA Phase I/II Trial

By MedXY 09/16/2025

The ENDOLA trial explored olaparib with metronomic cyclophosphamide and metformin, demonstrating a favorable safety profile and promising efficacy in heavily pretreated recurrent endometrial cancer patients, highlighting molecular subtype-dependent responses.

Clinical Updates Wellness & Lifestyle

Metformin in Gynecologic Cancers: A Comprehensive Review of Evidence in Cervical, Ovarian, and Endometrial Cancer

By MedXY 09/16/2025

This review synthesizes recent evidence on metformin's therapeutic and prognostic roles in cervical, ovarian, and endometrial cancers, highlighting randomized trials, meta-analyses, and clinical outcomes with a focus on progression-free and overall survival.

Clinical Updates Wellness & Lifestyle

Metformin as an Adjunct to Chemoradiotherapy in Locally Advanced Cervical Cancer: Insights on Safety, Tolerability, and Feasibility from a Phase II Randomized Trial

By MedXY 09/16/2025

This phase II study shows that adding metformin to standard chemoradiotherapy in locally advanced cervical cancer is safe, well tolerated, and feasible, with no significant increase in severe adverse events and successful biomarker-based tumor hypoxia assessments.

Clinical Updates Wellness & Lifestyle

Evaluating Metformin Addition to Paclitaxel/Carboplatin in Advanced and Recurrent Endometrial Cancer: Insights from an NRG Oncology/GOG Phase II/III Trial

By MedXY 09/16/2025

This phase II/III study assessed whether adding metformin to standard paclitaxel and carboplatin improved outcomes in advanced and recurrent endometrial cancer. The trial was stopped early due to lack of survival benefit and potential harm, highlighting the need for alternative therapeutic strategies.

Clinical Updates Wellness & Lifestyle

Vitamin D3 as a Potential Therapeutic Agent in Polycystic Ovary Syndrome: Insights from a Prospective Double-Blind Randomized Trial

By MedXY 09/16/2025

A recent double-blind randomized controlled trial demonstrates that weekly supplementation with vitamin D3 significantly improves ovarian morphology, menstrual regularity, and ovulation rates in women with PCOS, suggesting a role as standalone or adjunctive therapy.

Clinical Updates Wellness & Lifestyle

Enhanced Therapeutic Outcomes in Overweight/Obese Women with PCOS: Combining Metformin and Semaglutide

By MedXY 09/16/2025

Combination therapy with metformin and semaglutide improves weight loss, metabolic parameters, menstrual function, and natural pregnancy rates in overweight/obese women with PCOS compared to metformin alone.