Clinical Updates – Page 13

JAK Inhibitors and Venous Thromboembolism in Atopic Dermatitis: Clinical Risks and Practice Implications

By MedXY 07/30/2025

JAK inhibitors significantly increase the risk of venous thromboembolism compared to dupilumab and methotrexate in atopic dermatitis, underscoring the need for individualized risk stratification.

Clinical Updates

High Tibial Osteotomy May Slow Knee Osteoarthritis Progression in Bowlegged Patients: Clinical Insights from a Randomized Trial

By MedXY 07/30/2025

High tibial osteotomy (HTO) slows cartilage loss and improves pain and function in bowlegged patients with medial knee osteoarthritis compared to nonsurgical management, according to a new randomized trial.

Clinical Updates Wellness & Lifestyle

EMA Recommends First Oral On-Demand Therapy for Hereditary Angioedema: A Paradigm Shift in Acute Attack Management

By MedXY 07/30/2025

EMA endorses sebetralstat, the first oral on-demand therapy for hereditary angioedema, following positive results from the KONFIDENT phase 3 trial, offering a more convenient and rapid treatment option for acute attacks.

Clinical Updates Wellness & Lifestyle

EMA Recommends Voranigo for IDH-Mutant Grade 2 Glioma: A New Era in Targeted Brain Tumor Therapy

By MedXY 07/30/2025

The EMA’s CHMP recommends Voranigo, a dual IDH1/2 inhibitor, for grade 2 IDH-mutant gliomas, based on phase 3 INDIGO trial results demonstrating significant improvement in progression-free survival and delayed need for further therapy.

Clinical Updates Wellness & Lifestyle

Parathyroidectomy Enhances Muscle Health in Postmenopausal Women with Primary Hyperparathyroidism

By MedXY 07/30/2025

Surgical treatment of primary hyperparathyroidism in postmenopausal women significantly improves muscle strength, volume, and metabolic pathways linked to exercise, without increased physical activity.

Clinical Updates Wellness & Lifestyle

Unraveling the Drivers of Pruritus Severity in Intrahepatic Cholestasis of Pregnancy: Insights from a Longitudinal Cohort Study

By MedXY 07/30/2025

Peak bile acid levels and higher maternal BMI independently predict pruritus worsening in intrahepatic cholestasis of pregnancy, emphasizing the need for tailored monitoring and management as gestation advances.

Clinical Updates Wellness & Lifestyle

Early Postoperative PTH as a Reliable Predictor of Hypoparathyroidism After Total Thyroidectomy

By MedXY 07/30/2025

A single parathyroid hormone (PTH) measurement 6 hours after total thyroidectomy can accurately predict the risk of transient and permanent hypoparathyroidism, enabling targeted monitoring and potential reduction in hospital stays.

Clinical Updates Wellness & Lifestyle

Expanding Access to Chronic Pain Care: Telehealth and Online CBT-Based Interventions Show Promise

By MedXY 07/30/2025

Remote CBT-based interventions, delivered by telehealth or online modules, offer modest but significant improvements in pain and function for individuals with high-impact chronic pain, enhancing access to evidence-based care.

Clinical Updates Wellness & Lifestyle

Structured vs Self-Guided Multidomain Lifestyle Interventions for Cognitive Health: Insights from the US POINTER Randomized Clinical Trial

By MedXY 07/30/2025

A large US trial found that structured, intensive lifestyle interventions led to greater improvements in global cognition over two years compared to self-guided approaches among older adults at risk for cognitive decline.

Clinical Updates Wellness & Lifestyle

Demographic Data Gaps in FDA Authorization of AI-Based Devices for Alzheimer’s Disease and Related Dementias

By MedXY 07/30/2025

Limited demographic data transparency in FDA-authorized AI devices for Alzheimer’s may hinder equitable care and generalizability, highlighting a crucial need for improved dataset representativeness and regulatory oversight.