Clinical Updates – Page 11

Physical Activity Trajectories Before and After Cardiovascular Disease: Insights from the CARDIA Study

By MedXY 07/29/2025

Longitudinal data from CARDIA reveal declining physical activity before and after CVD events, with pronounced disparities among Black women, highlighting the need for targeted interventions across the life course.

Clinical Updates Medical News

Structured Lifestyle Intervention Shows Superior Cognitive Benefits in At-Risk Older Adults: Insights from the US POINTER Trial

By MedXY 07/29/2025

A large US trial shows that intensive, structured lifestyle programs yield greater cognitive improvement in at-risk older adults compared to self-guided approaches, though both are beneficial.

Clinical Updates Wellness & Lifestyle

Subclinical Primary Aldosteronism: A Hidden Driver of Cardiovascular Risk Beyond Blood Pressure

By MedXY 07/29/2025

Emerging evidence links subclinical primary aldosteronism to significantly increased cardiovascular risk, even in normotensive individuals, highlighting the need for refined screening and personalized hypertension management.

Clinical Updates Wellness & Lifestyle

Widespread Misclassification of Myocardial Infarction Subtypes in Administrative Coding: Implications for Practice and Policy

By MedXY 07/29/2025

Audit reveals major misclassification in hospital coding for myocardial infarction types, risking flawed epidemiology, reimbursement, and patient care.

Clinical Updates Wellness & Lifestyle

Increasing Sit-to-Stand Transitions Lowers Diastolic Blood Pressure in Sedentary Postmenopausal Women: Evidence from a Randomized Trial

By MedXY 07/29/2025

A 12-week randomized trial finds that increasing daily sit-to-stand transitions reduces diastolic blood pressure in sedentary, overweight, or obese postmenopausal women but does not significantly affect glucose regulation.

Clinical Updates

JAK Inhibitors and Thromboembolic Risk in Atopic Dermatitis: A Comparative Safety Signal

By MedXY 07/29/2025

A large real-world cohort study finds JAK inhibitors increase risk of venous thromboembolism versus dupilumab and methotrexate in atopic dermatitis, highlighting the need for individualized therapy.

Clinical Updates Medical News

Lecanemab in Community Practice: Real-World Safety and Efficacy for Early Alzheimer’s Disease

By MedXY 07/29/2025

Community-based data suggest lecanemab is safe and effective for early-stage Alzheimer’s, with manageable ARIA rates and infusion reactions, particularly in ApoE4 noncarriers.

Clinical Updates Medical News

Structured Lifestyle Interventions Deliver Superior Cognitive Benefits over Self-Guided Approaches in At-Risk Older Adults

By MedXY 07/29/2025

A large phase 3 trial reveals that structured, multidomain lifestyle interventions significantly improve cognition in older adults at risk for cognitive decline, outperforming self-guided strategies.

Clinical Updates Medical News

Alzheimer’s Association Releases First Clinical Guidelines for Blood-Based Biomarkers: Implications for Diagnosis and Practice

By MedXY 07/29/2025

New Alzheimer’s Association guidelines endorse blood-based biomarkers as diagnostic adjuncts, not standalone tests, emphasizing rigorous clinical evaluation and high test accuracy.

Clinical Updates Medical News

Synthetic Opioid Overdose Deaths Among Youth Surge 168%: A Five-Year Analysis and Clinical Implications

By MedXY 07/29/2025

Overdose deaths from synthetic opioids alone in U.S. youth aged 15–24 surged 168% between 2018 and 2022, now representing one-third of all youth OD fatalities. Clinical vigilance, harm reduction, and targeted prevention are urgently needed.